Monday, December 16, 2019
Review Of The Of The Imagination Essay - 1852 Words
CHAPTER ââ¬â II REALISM IN MARK TWAINS NOVELS According to Irving Babbitt, the imagination plays an all-important role in both literature and life. For Babbitt, society and politics are shaped by the imagination, because it is within the context of the imagination that oneââ¬â¢s reason and will inevitably function. He explains that man is cut off from immediate contact with anything abiding and therefore worthy to be called real, and condemned to live in an element of fiction or illusion, but he may lay hold with the aid of the imagination on the element of oneness that is inextricably blended with the manifoldness and change and to just that extent may build up a sound model for imitation. One tends to be an individualist with true standards only in so far as one understands the relation between appearance and realityââ¬âwhat the philosophers call the epistemological problem. For Babbitt, the development of a sound ethical center involves a degree of imitation and adherence to standards. What Babbitt has in mind is not slavish imitation of artificial external models but the careful building up of sound models for imitation. To accomplish this, one must be solidly anchored in reality and able to glimpse what Babbitt calls the one in the many. Claes Ryn has said that Babbittââ¬â¢s solution to the epistemological problem is to move closer to the truth above all by training the imagination, which is intimately related to the will. This is done negatively by unmaskingShow MoreRelatedSociological Imagination s Critical Review1319 Words à |à 6 PagesThe Sociological Imagination Critical Review Essay ââ¬Å"The sociological imagination enables us to grasp history and biography and the relations between the two within society. This is its task and its promise.â⬠C. Wright Mills writes about the sociological imagination in an attempt to have society become aware of the relationship between oneââ¬â¢s personal experience in comparison to the wider society. By employing the sociological imagination into the real world, individuals are forced to perceiveRead MoreNationalism and the Imagination by Gayatri Chakravorty Spivak555 Words à |à 3 PagesNationalism and the Imagination by Gayatri Chakravorty Spivak has being the hardest text I have read during my theory class at Sydney College of the Arts in 2014. My task was to read and explain the text to my theory class and my lecturer Dr Adam Geczy in 8 minutes as a YouTube video. This was an almost impossible task because Spivakââ¬â¢s Nationalism and the Imagination is a small book of 75 pages and at Sydney College of th e Artsââ¬â¢s library we are only able to borrow the book for 2 hours. I laterRead MoreThe Plain Sense Of Things By Wallace Stevens1017 Words à |à 5 Pagesof Thingsâ⬠creates an atmosphere of imagination, reality and symbolism of natural progression. Stated by POETRY FOUNDATION, Wallace Stevens is one of Americaââ¬â¢s most respected poets (Wallace Stevens, 2017). Wallace Stevens work is known for its imagination and relates to both English Romantics and French symbolists and is considered one of the major American poets of the century (Stevens, Wallace 2014). In ââ¬Å"The Plain Sense of Thingsâ⬠, it is evident that imagination is a huge aspect within the poem.Read MoreThe Sociological Imagination Essay1065 Words à |à 5 PagesPaper Grade: 75 / C The Sociological Imagination The sociological imagination is an idea or a way of thinking that interlocks an individual in a society with the society as a whole. Most people refer to sociology as the study of how people or individuals interact with each other. In order to fully understand sociology and the concept of the sociological imagination as proposed by C. Wright Mills, one has to be able to envision the individual and the society working together to better understandRead MoreCreativity And Imagination The Neverending Story 1304 Words à |à 6 Pages Creativity and Imagination in The Neverending Story Kasey Buse FYS 110Z: Creating/Imagining/Real Life Richard W. Swanson September 22, 2017 On my honor, I pledge that I have upheld the Honor Code, and that the work I have done on this assignment has been honest, and that the work of others in this class has, to the best of my knowledge, been honest as well. The Neverending Story is filled with a world of imagination and creativity and with imagination, our world can become a land of fantasyRead MoreThe Story Of Elisabeth Fritzl And Room By Lenny Abrahamson1264 Words à |à 6 Pagesreason why Joy could be authoritative parent because she still allows Jack to have an imagination which is important to childrenââ¬â¢s education because ââ¬Å"imagination is the source of all human achievementâ⬠(ââ¬Å"Importance of Imaginationâ⬠). In the film, Jack says that he has an imaginary dog named Lucky and he consistently says that so the audience can be reminded that Jack is a young child. Jack also uses his imagination and creativity to make egg snakes with his mother. There are also special rules thatRead MoreThe Silent Cinema872 Words à |à 4 Pagessilent filmââ¬âwinning Best Picture at the Academy Awards, it may be worthwhile to examine the nature and appeal of silent film. In a way, silent film does something that the mod ern day special effects spectaculars do not do: it leaves more to the imagination and calls upon the viewer to use his or her own mind in correspondence with the moving pictures. This paper will analyze what it is that makes silent film unique and show how the nature of silent film allows viewers to envision for themselves thoseRead MoreFantasy And Reality Are Two Opposing Themes1458 Words à |à 6 Pageshumanââ¬â¢s imagination is the birthplace of anything that is to come. A.M. Homes touches upon the darkest of things that can arise from the fantasies one creates. The End of Alice was written by A.M. Homes to display to the reader that the most horrifying thing about the world is our own imagination, thoughts, and fantasies. Throughout the novel, Homes creates graphic scenes that are constantly frightening the reader. Each scene is retold by Chappy, seemingly solely existing in his imagination. ThoughRead MoreThe World Is Flat- the Globalization World in the Twenty First Century- Book Review1672 Words à |à 7 PagesIntroduction to International Business Assignment Title: Individual Assignment ââ¬â Book Review Book title: The World Is Flat- the Globalization World in the Twenty First Century Author: Thomas L. Friedman Introduction ââ¬ËThe World Is Flat- the Globalization World in the Twenty First Centuryââ¬â¢ is a well written book by Thomas L. Friedman based on his personal experience, case studies, and etc. He explores the political and technological changes that have made the world a smaller place. From the explosionRead MoreFor this assignment I read the book reviews Limits of Endurance ââ¬ËDefiant,ââ¬â¢ by Alvin Townley; He700 Words à |à 3 PagesFor this assignment I read the book reviews Limits of Endurance ââ¬ËDefiant,ââ¬â¢ by Alvin Townley; He Accused ââ¬ËAn Officer and a Spy,ââ¬â¢ by Robert Harris; Breaking In ââ¬ËThe Burglary,ââ¬â¢ by Betty Medsger. For the book review Limits of Endurance ââ¬ËDefiant,ââ¬â¢ by Alvin Townley the reviewer seem to have thought fondly of this book while writing majority positive things about this novel. The review He Accused which went over the novel ââ¬ËAn Officer and a Spy,ââ¬â¢ by Robert Harris seemed to be majority mixed to the point
Sunday, December 8, 2019
Fraud Theory Analysis of the Zarmoon-Free-Samples for Students
Question: Write a Fraud Theory Analysis of the Zarmoon Inshanalli Case, and post your analysis to the Case Discussion 2 forum. Answer: Case Facts It can be noted that Ms. Inshanalli was charged of committing fraud under section 380(1) and 733.(1) of the Criminal code.She had pleaded guilty to the charge of committing fraud which amounted to more than $5000. It is to be stated that Ms. Inshanalli had been working in WSC Corporation Coppinwood Golf Club as a book keeper for a period of almost two years from April 2014 to January 2016. During the course of her employment Ms. Inshanalli had fraudulently written 134 cheques to herself. It is to be stated that all the cheques had been deposited into different bank accounts of Zamroon Nisha Inshanalli and were written to her name. Further 125 of the cheques written by her contained Gerard Waslens Signature, which she had forged. Zamroon Nisha Inshanalli is the wife of RaffiqInshanalli. They have a son who resides with them and is 34 years of age. Zamroon Niha Inshanalli is 62 years old. It was apparent that the son and husband of Ms. Inshanalli were aware of her fraudulent activities and her convictions in the past for the same reasons. It can be stated, in this case that the defendant had committed fraud amounting to $463,824.42. The defendant in this case, Ms Inshanalli however had made a restitution of $54,000. $409,824.42 were left as outstanding dues. Fraud theory analysis Numerous fraud theories can be used and applied in this case for analyzing the misconduct of the fraudsters and discuss the main reasons for committing fraud by fraudsters (Morales, Gendron Gunin-Paracini, 2014). The fraud theories that will be applied in this case are: Fraud Triangle theory This theory states that three different factors can transform a person who is trustworthy to a fraudster. The aforementioned factors are: Perceived Pressure The motivation to commit fraud is provided to the fraudsters by the perceived pressure (Schuchter Levi, 2015). At times trustworthy people resort to committing fraud as a result of facing acute financial problems which cannot be solved lawfully. As a result of facing such financial problems trustworthy people resort to illegal and unethical standards. Perceived opportunity- It is to be mentioned that a person, who is trustworthy commits a fraudulent activity when he finds an opportunity to take advantage of the victims trust (Free, 2015). This factor provides explanation of how the fraud takes place. Rationalization- It is to be noted that most fraudsters are not criminals and therefore they can personally justify the reasons for committing frauds. However, the principle of rationalization is not to be applied to assess the reason of committing fraud by predatory fraudsters. The factors of the fraud triangle theory cannot be implemented in this chosen case as it has been noted that Ms Inshanalli had been convicted of fraudulent activities in the past on two occasions. Her first conviction was on May 13 2004 for a theft of $750,000. She had again committed theft of $141,000 over a time period of two years from 2010 to 2012 from her employer, Sherwood Innovations. On the second occasion she had pleaded guilty and had to serve an eighteen month conditional sentence followed by a probation period of two years. Therefore after analyzing the aforementioned facts it is to be said that her behavior resembles that of predatory fraudster. The Fraud Scale It can be said that this theory came into being in the 1984 and it substituted the theory of fraud triangle. The Fraud Scale theory considers the factor integrity in addition to the al other factors of the theory of Fraud Triangle (Schuchter Levi, 2015). The commitment of a person to ethics is the factor that assesses the integrity of the person. Therefore it can be stated that a person acting under low pressure, with low opportunity and high integrity is less expected to commit fraud than some who has low integrity, high opportunity and under high pressure. In this chosen case study it can be stated that the principles of fraud scale theory cannot be completely applied as the defendant, Ms Inshanalli had exhibited similar conduct on numerous occasions in the past. However, the factor integrity can be assessed in this given scenario. She had exhibited low integrity and was presented with high opportunity. The combination of these two factors increased her chances of committing fraud Rational Choice Theory It is to be stated that this theory has three main and main conditions of fraud. They are: Individuals aim and act to fulfill their self interest. Individuals aim to maximize their personal goals The fraudster often places his own interests above the interest of any other party. The rational theory suggests that offenders commit a crime after evaluating the benefits to be acquired by the crime and consequences of committing the same (Anand, Dacin Murphy, 2015). In the aforementioned case it can be stated that the defendant had committed fraud on numerous occasions as she had perceived that it was easy to get away with it. She had committed the frauds to improve her well being and financial status which seemed to be of greater importance than the consequence of it. Conclusion Thus to conclude it is be stated that all the theories discussed above have been able to analyze the factors that drive individuals to commit fraud. It is to be stated that in the R vs Paterson, 2013, case it was analyzed by the court that the defendants main motive to commit fraud was to recover from the financial crisis faced by him due to his failing business. Thus by applying the theory of fraud triangle it is to be said that the defendant had been under a lot of pressure and thus seized the opportunity to take advantage of his position. It is mainly due to this reason that he committed the fraud. In this case the defendant was not under any pressure and she committed fraud primarily because she wanted to improve her financial status and her well being. By the application of the Rationalization theory it is to be said that she had committed the crimes as she had assessed that the consequences of the crimes likely to be faced by her were outweighed by the benefit of the crime. Bibliography: Anand, V., Dacin, M. T., Murphy, P. R. (2015). The continued need for diversity in fraud research.Journal of Business Ethics,131(4), 751-755. Free, C. (2015). Looking through the fraud triangle: A review and call for new directions.Meditari Accountancy Research,23(2), 175-196. Morales, J., Gendron, Y., Gunin-Paracini, H. (2014). The construction of the risky individual and vigilant organization: A genealogy of the fraud triangle.Accounting, Organizations and Society,39(3), 170-194. v. Inshanalli, 2017 ONCJ 234 v. Paterson, 2013 BCPC 5 Schuchter, A., Levi, M. (2015, September). Beyond the fraud triangle: Swiss and Austrian elite fraudsters. In Accounting Forum(Vol. 39, No. 3, pp. 176-187). Elsevier. Schuchter, A., Levi, M. (2015, September). Beyond the fraud triangle: Swiss and Austrian elite fraudsters. InAccounting Forum(Vol. 39, No. 3, pp. 176-187). Elsevier. Schuchter, A., Levi, M. (2016). The fraud triangle revisited.Security Journal,29(2), 107-121.
Sunday, December 1, 2019
Marketing Simulation Essay Example Essay Example
Marketing Simulation Essay Example Paper Marketing Simulation Essay Introduction Orange experienced a very successful campaign and grew more profitable over the six quarters throughtout the Market Simulation. In terms of market share in comparison to the competition, we placed fourth holding 12 percent market share. We initially targeted the Mercedes market, and later developed products aimed at the Traveler and Workhorse clientele. In terms of profitability, we suffered a loss moving from Quarter 1 to Quarter 2, which is typical of most early-stage companies. However, each quarter thereafter we were able to maintain a profit, ending with $18,270,122 gross profit and $15,232,910 operating profit. Our six computer models are the driving factor behind such success. These models include The Motherboard, Babyboard 2. 0, Horseboard, Superboard, Toddlerboard, and The Ponyboard. The Superboard, out of all the models, was our most profitable device with $6,303,840 in profit. We also embarked on a major expansion endeavor, spreading our brand originally from Chicago to Pa ris, Shanghai, and Sao Paulo. Our knowledgeable sales force comprised of 60 individuals, coupled with our extensive advertising and competitive pricing allowed Orange to rise to the top. By the end of the Marketplace Simulation, Orange was in first place for cumulative total performance, accounting for a variety of business disciplines that contributed to our success. While we placed third in the simulation in terms of overall financial performance, we placed first overall for market performance and marketing effectiveness. Brand Design: Over the course of the six quarters, we made varying adjustments to our brands in order to keep up with the ever-changing competitive markets. Marketing Simulation Essay Body Paragraphs In Quarter 2, we decided to enter the Mercedes market with The Motherboard computer. Specifically, this brand was designed to be the top of the line product that suited all the most important needs of Mercedes. Some of these needs included a fast and powerful processor, the ability to link with other computers, and a machine that is capable of multitasking (Fig 1. 1). We figured that starting out in the highest-end market would be beneficial to creating a good name for our company, and then we would be able to trickle down throughout the other brandstarget market segments. Our results from Quarter 2 showed that we were successful with The Motherboard, as we possessed 46 percent of the market share for Mercedes. In Quarter 3, we introduced The Babyboard to the Traveler market segment. We designed our product to match the best-suited brand for Traveler, which was SwifTechââ¬â¢s Quickfly. We were slow to expand from our original two brands, and lost some of our momentum with our Quar ter 4 decisions. When we got our results, we realized that we needed to introduce more brands in order to keep up with the highly competitive markets. Quarter 5 marked our first Quarter quarter of rapid expansion. We introduced an additional product lines to Mercedes and Traveler, and created our first unit product for Workhorse. The new product lines for Mercedes and Traveler, The Superboard and The Toddlerboard respectively, were the higher quality versions of the The Motherboard and the The Babyboard. They , which were enhanced with all of the necessities and priced slightly higher than the original lines. Our initial brand for Workhorse was the The Horseboard, and it possessed the most basic features at the lowest price, to appeal to a consumer who was looking for something simple to use. We continued the trend of making two slightly varied products for each market segment in Quarter 6 when we introduced the The Ponyboard to supplement a slightly lower-end product than the The H orseboard. Sales Design Strategy: The sales design strategy of Orange was based primarily on the customerââ¬â¢s (Workhorse, Mercedes and Traveler) needs and wants. This consisted of the top eight preferences in either a laptop or a desktop, and the top six segments of applications. Additionally, each of the target marketââ¬â¢s priceprices willing to pay is are shown in (Fig 1. 2). Initially, Orange felt it was most appropriate to choose to target the Mercedes market in Chicago. This allowed for The Motherboard to be produced, which led to 46 percent% domination in only the Mercedes market. Unfortunately overall Orange only had a 12 percent% overall market share, and felt it was necessary to expand into the portable laptop industry of Traveler with The Babyboard 2. 0, and opened a plant in Paris. By Quarter 3, the market size had reached 10,000 customers, which allowed for expansion in the cities of Shanghai and Sao Paulo, and the last target market of Workhorse. The generous r ebates were attractive to the target audience, and allowed for the introduction of The Horseboard, The Superboard, and The Toddlerboard. By Quarter 6, a total of 60 sales people had been employed, and due to the overall low prices of the products, as well as the rebates, Orange gained a 2 percent% market share. Financial Performance: Throughout these first phases of our company, Orange has created a positive financial pattern. While we implemented an aggressive growth strategy and expanded our empire internationally, we kept our costs to a minimum. Naturally, we started Quarter 2 with a deficit due to startup costs. Unlike most companies, our costs were controlled however, and we were only behind by just over $12,000. As advertising has always been a core competency of our company, we spent a total of $109,471 developing and promoting our first batch of advertising. The leasing costs and office spaces were kept to a minimum in the first two quarters as well, since we were only opera ting out of one location. As we moved into the Quarter 3, we expanded internationally and our rental costs increased. However, our sales skyrocketed as well. We had begun to turn a profit, and were in the black by $1,155,328. In Quarter 4, we continued the pattern of financial growth, and maintained an increase in sales. Again, we were fiscally conservative and attempted to keep costs to a minimum (Fig. 1. 3). An important component of Orangeââ¬â¢s financial history is the profitability of each brand we sell (Fig 1. 4). Our first line, The Motherboard, dedicated to the top-tier consumer, introduced us to the marketplace. We turned a profit of $922,344 throughout all six quarters. This is a modest percentage of our empire, yet it accounts for the beginnings of our financial gain. Our most profitable brand, The Superboard, generated $6,303,840. We invested a lot of time and capital in the creation of this line, and it paid off. The ToddlerbBoard, HorsebBoard, and PonybBoard were al l profitable as well, with over one million made from each. Financially, only one of our lines performed less well than we had hoped. Our second line, The Babyboard 2. 0 only generated $452,198. Unfortunately, we were unable to sell a high number of these units, and the cost of goods sold was very high in comparison. In the end, each of our brands was able to generate profits. Our conservative fiscal policy allowed enough room for growth without spending more than we could handle. Finally, our revenues continued in a positive direction throughout every quarter, and we are confident the future will play out in the same way (Fig 1. 5). Competition: In the computer market, competition is very fierce. Thus, our company had to constantly position itself to be able to compete with the other companies in the market. To this end, we opened our first sales office in Chicago, hoping that our knowledge of the American marketplace would aid us in capturing a large initial market share. This pla n was successful and put us near the top in overall performance in the computer market. From this point, our company decided that in order to continue our success, we needed to examine the competition to find out what we were doing right, what we were doing wrong, and how we could improve. This plan enabled us to better understand what customers wanted without having to invest heavily into producing prototypes, because we were able to utilize other companyââ¬â¢s products and sales numbers as though they were test products. Our first major interaction with our competition came in Quarter 4our fourth Quarter of operation. We introduced our The Babyboard product for the Traveler segment in our third QuarterQuarter 3 of operation. We made the mistake however, of not considering the Traveler segmentââ¬â¢s desire for the computer to be fun to use. We discovered this issue by examining our competitorââ¬â¢s products and finding that all competitors that were more successful than us had included games with their product. Despite the increased costs of production and the cost of redesigning our brand, profits for the The Babyboard nearly doubled the next qQuarter (Fig. 1. 6). We also looked to our competition to determine our expansion plans. We realized immediately that with such fierce competition, the first mover advantage would be crucial. Thus, we expanded as quickly as possible by opening sales offices in every possible location. We also handled competition by expanding into every market segment, eventually offering a product for all segments of the market. Our company felt that this strategy would ensure that even if the competition would overtake us in one area, we would be able to survive on the strength of our other products while we figured out how to react. This strategy ultimately served our company well, as we were the top overall performer in the computer market. Conclusion The results of the past six quarters have clearly shown that Orange has m et its primary goals and exceeded expectations, becoming one of the most consistent and profitable companies in the industry. By using a conservative fiscal policy as well as an aggressive and competitive expansionary policy, we have seen Orange grow and become a stable company that is definitely worthy of further investment. To put it into a more detailed perspective, the way we dealt with competition, brand management, sales strategy, and our financials, was what brought us to the top and remains the reason we plan on becoming even more profitable in the near future. By starting in the Mercedes market, we were able to establish ourselves early as a company that promotes high-end, top quality products. This made it extremely easy in the future to expand to the other brands such as Traveler and Workhorse, since we were already best known for our superior products, that we have constantly updated to satisfy the ever changing consumer demands. By using this strategy, we were eventuall y able to generate enough revenue to expand to four different areas of the world, making our brands even better known and reaping most of the first mover advantages. However, this idea alone was not sufficient to achieve the revenues that we experienced over the past few quarters. Additionally, we knew that for our company to be profitable, we needed to get our name out there. This is why our strategy was to hire a large amount of sales people in each country, and invest a large sum of our operating capital in advertisements that would appeal to the wants and needs of specific target markets. Though we have experienced relative success the past six quarters that have propelled us to the top of the industry in overall performance, we are owhere near complacent. With the competition so fierce and the landscape of the technological environment constantly changing, we feel that we are prepared to respond to any competitive and technological pressures that we might have to face in the fu ture. Our company has been the model company in terms of consistency and financial growth and we feel as though our results so far have proven that Orange is a safe investment that will provide lucrative returns in the future. Figure 1. 1 Figure 1. 2 Figure 1. 3 Figure 1. 4 Fig 1. 5 Fig 1. 6 We will write a custom essay sample on Marketing Simulation Essay Example specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Marketing Simulation Essay Example specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Marketing Simulation Essay Example specifically for you FOR ONLY $16.38 $13.9/page Hire Writer
Tuesday, November 26, 2019
FDR versus Hitler essays
FDR versus Hitler essays Franklin D. Roosevelt and Adolph Hitler were two of the most influential leaders in modern history. They had diametrically different views on leading their respective nations, as well as what purpose their leadership would serve. Their styles as leaders shaped their views and determined what actions they would take leading up to and through out World War II. I will compare both Hitler and Roosevelt's leadership styles as they applied to World War II. Conclusively, I will show that, while they were two completely different types of leaders, they were both very effective and did what they thought would best serve their countries. In January of 1941, President Franklin Delano Roosevelt pronounced in his address of the Four Freedoms that we, and our allies, need to free the peoples of Europe from Hitler's tyrannical rule. Roosevelt has often been criticized for not entering the war earlier and stopping the killing he knew was occurring. However, as is always the case in America, the President had pressure from all directions. As a result, Roosevelt had to give most of his assistance to the warring nations in private until America did finally enter the conflict because of Japan's attack on Pearl Harbor. Roosevelt frequently conducted radio broadcasts to inform, calm and rally the American masses. It is often mentioned that people felt in touch with Roosevelt and seemed as though he was right there in their living rooms with them. Franklin Roosevelts first inaugural speech was one of the most famous speeches in documented history. We have nothing to fear but fear itself, was very moving. He calmed the fears of millions of Americans. His charisma and keen political positioning allowed him remain out of the war until America was behind the effort. Once the effort was started every American put forth the effort he asked for to defeat the Axis powers. Roosevelt is known today as arguably one of the best p...
Friday, November 22, 2019
Phosphorylation and How It Works
Phosphorylation and How It Works Phosphorylation is the chemical addition of a phosphoryl group (PO3-) to an organic molecule. The removal of a phosphoryl group is called dephosphorylation. Both phosphorylation and dephosphorylation are carried out by enzymes (e.g., kinases, phosphotransferases). Phosphorylation is important in the fields of biochemistry and molecular biology because its a key reaction in protein and enzyme function, sugar metabolism, and energy storage and release. Purposes of Phosphorylation Phosphorylation plays a critical regulatory role in cells. Its functionsà include: Important for glycolysisUsed for protein-protein interactionUsed in protein degradationRegulates enzyme inhibitionMaintains homeostasis by regulating energy-requiring chemical reactions Types of Phosphorylation Many types of molecules can undergo phosphorylation and dephosphorylation. Three of the most important types of phosphorylation are glucose phosphorylation, protein phosphorylation, and oxidative phosphorylation. Glucose Phosphorylation Glucose and other sugars are often phosphorylated as the first step of their catabolism. For example, the first step of glycolysis of D-glucose is its conversion into D-glucose-6-phosphate. Glucose is a small molecule that readily permeates cells. Phosphorylation forms a larger molecule that cant easily enter tissue. So, phosphorylation is criticalà for regulating blood glucose concentration. Glucose concentration, in turn, is directly related to glycogen formation. Glucose phosphorylation is also linked to cardiac growth. Protein Phosphorylation Phoebus Levene at the Rockefeller Institute for Medical Research was the first to identify a phosphorylated protein (phosvitin) in 1906, but enzymatic phosphorylation of proteins wasnt described until the 1930s. Protein phosphorylation occurs when the phosphoryl group is added to an amino acid. Usually, the amino acid is serine, although phosphorylation also occurs on threonine and tyrosine in eukaryotes and histidine in prokaryotes. This is an esterification reaction where a phosphate group reacts with the hydroxyl (-OH) group of a serine, threonine, or tyrosine side chain. The enzyme protein kinase covalently binds a phosphate group to the amino acid. The precise mechanism differs somewhat between prokaryotes and eukaryotes. The best-studied forms of phosphorylation are posttranslational modifications (PTM), which means the proteins are phosphorylated after translation from an RNA template. The reverse reaction, dephosphorylation, is catalyzed by protein phosphatases. An important example of protein phosphorylation is the phosphorylation of histones. In eukaryotes, DNA is associated with histone proteins to form chromatin. Histone phosphorylation modifies the structure of chromatin and alters its protein-protein and DNA-protein interactions. Usually, phosphorylation occurs when DNA is damaged, opening up space around broken DNA so that repair mechanisms can do their work. In addition to its importance in DNA repair, protein phosphorylation plays a key role in metabolism and signaling pathways. Oxidative Phosphorylation Oxidative phosphorylation is how a cell stores and releases chemical energy. In a eukaryotic cell, the reactions occur within the mitochondria. Oxidative phosphorylation consists of the reactions of the electron transport chain and those of chemiosmosis. In summary, redox reaction pass electrons from proteins and other molecules along the electron transport chain in the inner membrane of the mitochondria, releasing energy that is used to make adenosine triphosphate (ATP) in chemiosmosis. In this process, NADH and FADH2 deliverà electrons to the electron transport chain. Electrons move from higher energy to lower energy as they progress along the chain, releasing energy along the way. Part of this energy goes to pumping hydrogen ions (H) to form an electrochemical gradient. At the end of the chain, electrons are transferred to oxygen, which bond with H to form water. H ions supply the energy for ATP synthase to synthesize ATP. When ATP is dephosphorylated, cleaving the phosphate group releases energy in a form the cell can use. Adenosine is not the only base that undergoes phosphorylation to form AMP, ADP, and ATP. For example, guanosine may also form GMP, GDP, and GTP. Detecting Phosphorylation Whether or not a molecule has been phosphorylated can be detected using antibodies, electrophoresis, or mass spectrometry. However, identifying and characterizing phosphorylation sites is difficult. Isotope labeling is often used, in conjunction with fluorescence, electrophoresis, and immunoassays. Sources Kresge, Nicole; Simoni, Robert D.; Hill, Robert L. (2011-01-21). The Process of Reversible Phosphorylation: the Work of Edmond H. Fischer. Journal of Biological Chemistry. 286 (3).Sharma, Saumya; Guthrie, Patrick H.; Chan, Suzanne S.; Haq, Syed; Taegtmeyer, Heinrich (2007-10-01). Glucose Phosphorylation Is Required for Insulin-Dependent mTOR Signalling in the Heart. Cardiovascular Research. 76 (1): 71ââ¬â80.
Thursday, November 21, 2019
Evaluation of the Utilisation of Cataract Surgery Services in South Article
Evaluation of the Utilisation of Cataract Surgery Services in South India - Article Example Blindness is a major health problem in India. It has been estimated that about 12 million people are suffering from blindness in India, the dominant cause of which is cataract. Cataract accounts for nearly two-third of blind population in India. The Government of India launched National Programme for Control of Blindness in 1976 and the World Bank Assisted Cataract Blindness Control Project in 1994, with the aim to bring down the incidence of blindness from 1.4% to 0.3%. To achieve this, eye care infrastructure and human resources were developed, accessibility to eye care services were increased and quality of eye care services was improved. As a result, many cataract surgeries were performed and are being performed at various visual camps to restore vision of the affected persons. Cataract is easily treatable by surgery. Though extracapsular cataract extraction (ECCE) is much better than intracapsular cataract extraction (ICCE) in terms of outcome and patient satisfaction, not many surgeons are trained in ECCE. Also, it is much costlier and takes longer time. Consequently, a substantial part of cataract extractions are still performed as ICCEs. In a study by Nirmalan et al (2004), it has been reported that a large proportion of people who required eye care did not utilize eye care services at the time. In our study, we would like to evaluate the utilization of cataract surgery services mainly in South India and find out reasons for not utilization so that policies can be recommended to improve these health services.
Tuesday, November 19, 2019
Migraine Pain Research Paper Example | Topics and Well Written Essays - 250 words
Migraine Pain - Research Paper Example Migraine is distinguished from normal or tension headache on the basis of factors or reasons behind its generation. It is important to understand that migraine is not typical fluctuation in blood pressure or increased intracranial pressure. Migraine attacks may contribute to neurosis, one-time or permanent. It effects the neuroendocrine system (including adrenal and thyroid gland), which is responsible for the generation of neuroses in the body. The constant production of stress hormones, including adrenaline leads to vasoconstriction. It is not possible to clearly identify the specific cause behind the emergence and development of migraine. There have been cases in which it is found that the migraine is genetically transferred to people. However, there are peculiar reasons for migraine in every case (Thakar, Anjaneyulu, and Deka, 2001). Migraine patient also suffers from photophobia and phonophobia (light and zvukoboyazn). Bright lights and any sharp sound can cause excruciating throbbing headache. There is increased irritability and sudden mood swings. The sharp smell can also act as irritants, causing nausea, vomiting, dizziness, loss of orientation in space. The patient may experience severe pain not only in the head, but also in neck, eyes, and upper jaw (Cutrer, ODonnell, and Sanchez, 2000). Before diagnosing the patient with migraine pain it is important to evaluate the history of the patients clinical and evolutionary process, ruling out diseases that can mask the symptoms of migraine. For this purpose physicians can use the brain scan through Cranial CT scan and magnetic resonance imaging (MRI) (Thakar, Anjaneyulu, and Deka,
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